Development site - https://dev2.circadianlight.com/

CIRCADIAN LIGHT RESEARCH CENTER

Optimizing Light for Human Health and Performance

floorPlanLocated on Boston’s Rt 128 High Tech Corridor

Dr Martin Moore-Ede, a former professor at Harvard Medical School, and his biomedical engineering research team built this medical research center to identify and develop the optimal lighting for 24/7 operations. With funding from the National Institutes of Health and other supporters they designed and operated light-controlled medical research center with fully spectrally-controlled workplace and residential lighting, to study human volunteers living and working shifts around the clock. 

As lighting with carefully controlled spectral content is delivered, a full range of physiological, psychological performance and medical tests are undertaken including

  • Sleep and wakefulness with continuous EEG monitoring
  • Blood tests (lipids, cardiac markers)
  • Glucose Tolerance tests (Diabetes)
  • 24-hour urine melatonin collection
  • Salivary Melatonin 30-minute intervals
  • Blood pressure
  • Alertness & performance tests
  • Mood and Depression scale test
Full ethical protection of our volunteers is provided. Each participant gave written informed consent after receiving a full explanation of the study purpose, design, and procedures. Study protocols and consent forms are reviewed and approved by the Circadian Institutional Review Board (IRB# 00001522) registered for Federal Wide Assurance (FWA) with the Office for Human Research Protections (OHRP) of the Department of Health and Human Services (HHS).  

Accomplishments
  • Identification of narrow band of 440-490nm blue light which disrupts circadian clocks at night, and elucidation of the light-adapted circadian spectral sensitivity curve.
  • Development of spectrally-engineered white light LEDs which remove critical blue wavelengths without causing yellow light.
  • Testing of multiple light fixtures to determine which best optimize human health markers such as insulin resistance, melatonin levels and sleep
  • Demonstration that blue depleted white light at workplace illumination levels can prevent the circadian disruption, melatonin suppression, excessive hunger and reduced vigilance caused by conventional blue-pump LEDs.
  • Development and testing of control systems which track the natural sunrise and sunset across the seasons of the year, and keep interior lighting in-sync with the external environment

 

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Headquarters
  • 2 Main Street, Suite 310
    Stoneham, MA, 02180, USA
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  • 1-781-439-6333
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